In this method, it is possible to use active/viable animal or human brain slices / cells (normal or disease model) to study the effects of different drugs on brain cells (neuron or glia) in diverse brain region.

Last updated on: 10-09-2019 - 09:50

Contact: Surajit Sahu
Organisation: Vrije Universiteit Brussel
Status: History of use, Published in peer reviewed journal

Better understanding of molecular mechanisms controlling both normal and malignant human hematopoiesis will lead to a more efficient therapy of immune deficiencies and lymphoid leukemias. Therefore, human hematopoietic progenitor cells (HPCs) are differentiated in vitro towards distinct

Last updated on: 30-08-2019 - 10:36

Contact: Tom Taghon
Organisation: Ghent University
Status: Internally validated, Published in peer reviewed journal

Sandwich-cultured hepatocytes are exposed to test compounds (e.g. drug candidates) or known hepatotoxicants (as controls) both in the absence and in the presence of a mixture of physiologically relevant bile acids. After 24h, decreased hepatocyte viability and functionality in the presence of

Last updated on: 30-08-2019 - 09:25

Contact: Pieter Annaert
Organisation: KU Leuven
Status: Internally validated, Published in peer reviewed journal

Recent improvements on the structural aspects of organ-on-chips pave the way towards a large-scale application. As such soon the number of read-out instruments that are in operation in parallel will need to drastically increase. Unfortunately, standard read-out equipment is bulky, complex and

Last updated on: 27-08-2019 - 18:22

Organisation: Vrije Universiteit Brussel
Status: Still in development

Despite major advances in our understanding of neurodegenerative disorders, no efficient therapies are available for patients with dementia, motor neuron disease and other neurodegenerative disorders. With the advent of pluripotent stem cells (PSCs) it now becomes possible to better model human

Last updated on: 27-08-2019 - 18:22

Contact: Cannot be disclosed
Organisation: KU Leuven
Status: Still in development, Internally validated

With a one vessel fermentor (BioFlo 110, New Brunswick), an in vitro simulation of a certain part of the gastrointestinal tract (e.g. cecum, colon) is performed. In this fermentation system, physiological gut parameters (pH, temperature) are kept constant, while chemico-physical

Last updated on: 27-08-2019 - 18:17

Contact: Marc Heyndrickx
Organisation: Flanders Research Institute for Agriculture
Status: History of use, Internally validated, Published in peer reviewed journal

This method describes the steps from a living mouse to a multicellular brain slice model where complex cellular interactions can be evaluated

Last updated on: 27-08-2019 - 18:16

Contact: Melissa Schepers
Organisation: Hasselt University
Status: Still in development

This method is used to monitor cardiac cell cultures in vitro. It can be used for monitoring both cell activity and drug-induced cardiac side-effects for primary cardiomyocytes or hIPSC-derived cardiomyocytes. Unlike conventional microelectrode array systems that only measure the local

Last updated on: 26-08-2019 - 14:16

Contact: Thomas Pauwelyn
Organisation: IMEC
Status: Published in peer reviewed journal

We developed in vitro models to study liver disease, such as liver inflammation and fibrosis, as seen in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH); or hepatitis viral infection; or to enhance our ability to detect drugs that cause acute or repeat dose

Last updated on: 26-08-2019 - 13:56

Contact: Cannot be disclosed
Organisation: KU Leuven
Status: Internally validated, Published in peer reviewed journal