It is the goal of the DNA-adductomics to search for DNA-adducts that might be formed during interaction with contaminants. The analysis of DNA adducts is performed using ultra-high performance liquid chromatography coupled to hybrid quadrupole-Orbitrap high resolution mass spectrometry. Both the

Last updated on: 12-11-2019 - 11:16

Contact: Lynn Vanhaecke
Organisation: Ghent University
Status: Internally validated, Published in peer reviewed journal
Our polar metabolomics profiling and fingerprinting methodology applies ultra-high performance liquid chromatography coupled to hybrid quadrupole-Orbitrap high resolution mass spectrometry. Both the instrumental method, as well as generic extraction protocols for colon tissue, cell cultures, urine,

Last updated on: 12-11-2019 - 11:13

Contact: Lynn Vanhaecke
Organisation: Ghent University
Status: Internally validated, Published in peer reviewed journal
Our lipidomics profiling and fingerprinting methodology enables the analysis of all lipids within a biological matrix. These lipids can then be compared between an individual or condition with a specific metabolic state and healthy controls to find biomarkers or pathways that can be related to

Last updated on: 08-11-2019 - 14:12

Contact: Lynn Vanhaecke
Organisation: Ghent University
Status: History of use, Internally validated, Published in peer reviewed journal
The DPRA is an in chemico method which quantifies the remaining concentration of cysteine- or lysine-containing peptide following 24 hours incubation with the test chemical at 25 +/-2,5ºC. The synthetic peptides contain phenylalanine to aid in the detection. Relative peptide concentration is

Last updated on: 08-11-2019 - 10:21

Contact: bart Desmedt
Organisation: Sciensano
Partners: Sciensano
Status: History of use, Internally validated, Validated by an external party (e.g. OECD, EURL ECVAM,…)