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[(gem,)-360.5(Belgium\).)-355.7(The)-357(concentrations)-360.1(of)-353.5(1)-352.4(and)-355.8(4)-168.1(mg/L)-352.5(repre-)]TJ
0 -1.1174 TD
[(sent)-351.1(the)-344.4(upper)-352.2(and)-344.3(lower)-347.5(limits)-348(of)-347.7(intestinal)-347.9(concentrations)]TJ
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[(in)-532.2(pigs)-534.2(exposed)-534(to)-532.2(feed)-530.8(containing)-537.9(3%)-527.4(of)-532.1(the)-534.5(MRD)-530.2(of)]TJ
T*
(DOX.)Tj
7.3823 0 0 6.5614 336.7558 290.381 Tm
(10)Tj
9.843 0 0 9.843 348.2078 286.0157 Tm
[(In)-411.1(addition,)-411.2(we)-407.4(tested)-412.2(16)-169.2(mg/L)-410.1(DOX)-409.1(as)-412.1(this)-413.4(con-)]TJ
-3.571 -1.1174 TD
[(centration)-377.7(is)-370.8(above)-370.7(the)-373.2(epidemiological)-374.4(cutoff)-376.5(values)-371.7(\(EC-)]TJ
0 -1.1116 TD
[(OFF\))-367.8(of)-359.3(doxycycline)-361.5(for)-366.1(all)-361.8(species)-362.3(listed)-365.1(in)-359.4(the)-361.7(EUCAST)]TJ
ET
q
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487.389 114.179 l
126.822 114.179 l
W n
q
360.926 0 0 127.956 126.822 114.179 cm
/Im1 Do
Q
Q
BT
/F7 1 Tf
9.845 0 0 9.845 62.022 96.6047 Tm
[(FIG.)-302.2(1.)]TJ
/F5 1 Tf
4.0828 0 TD
[(Chronology)-299(of)-301.4(a)-301.6(reactor)-304.3(run.)-300(Samples)-303.9(for)-302.4(plating)-296.6(and)-303.6(DNA)-304.9(extraction)-301.9(were)-300.8(collected)-307.8(at)-297(9:00)-303.6(every)-301(morning.)-299.6(On)]TJ
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[(day)-286.3(0,)-280.8(the)-286.5(reactor)-287(was)-287(inoculated)-284.6(with)-287.3(a)-284.3(pooled)-283.7(cecal)-286.2(inoculum)-287(and)-286.3(operated)-282.3(as)-285.2(a)-284.3(batch)-289.6(culture)-286(during)-282.5(24)-163.2(hr.)-287.5(During)-283.4(day)-286.3(1,)]TJ
0 -1.0135 TD
[(the)-430.5(feed)-426.7(medium)-430(was)-430.9(prepared)-431.8(and)-430.3(the)-430.5(reactor)-431(changes)-430.6(to)-428.3(continuous)-431.6(culture.)-427.6(After)-433.3(sample)-429.8(collection)-428.7(on)-428.1(day)-430.3(5,)-430.5(feed)]TJ
T*
[(medium)-234.2(was)-235.1(supplemented)-235.6(with)-235.5(1,)-234.7(4,)-234.7(or)-232.3(16)-169(mg/L)-231.1(DOX.)-239.1(Six)-233.3(hours)-229.4(after)-237.8(starting)-234(continuous)-235.8(administration)-236.9(of)-238.1(doxycycline,)-231.2(an)]TJ
T*
[(extra)-335.7(sample)-337.7(was)-333(collected)-336.6(for)-337(plating)-331.1(and)-338.1(DNA)-333.7(extraction.)-339.8(DOX,)-331.3(doxycycline)-337.2(hyclate.)]TJ
/F8 1 Tf
8.9663 0 0 8.9663 62.022 749.6502 Tm
(2)Tj
45.114 0 TD
[(DE)-335.8(MULDER)-336.1(ET)-338.7(AL.)]TJ
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