The Chorioallantoic Membrane (CAM) assay is a versatile, cost-effective in ovo model using the vascular-rich membrane of fertilized chicken eggs to study biological processes such as angiogenesis, tumor growth, metastasis, and drug testing. Its transparency and rapid vascularization make it ideal
Last updated on: 19-12-2024 - 11:45
Contact: Lotte Alders
Organisation: University of Hasselt (UHasselt)
Status: History of use, Published in peer reviewed journal
Human duodenal biopsies from metabolic dysfunction-associated steatohepatitis (MASH) patients were used to generate organoids and then investigate potential alterations in intestinal barrier and absorptive functions.
Last updated on: 19-12-2024 - 09:15
Contact: Marie-Isabelle Garcia
Organisation: Université Libre de Bruxelles (ULB)
Partners: Université Libre de Bruxelles (ULB)
Status: Published in peer reviewed journal
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were seeded in 48-well multielectrode array (MEA) plates and were treated with four doses of reference compounds (covering and exceeding clinical free plasma peak concentrations) and MEA recordings were conducted for 4 days.
Last updated on: 13-12-2024 - 14:46
Contact: Cannot be disclosed
Organisation: Janssen Pharma of JNJ
Status: Internally validated, Published in peer reviewed journal
Design and fabrication of a method to enhance the cost-effectiveness of organoid culturing and drug screening assays by miniaturizing the cultures and reduce the required reagent volumes to the sub-nanoliter range through microfluidic techniques. By growing single or multiple organoids per microbead
Last updated on: 02-12-2024 - 15:51
Contact: Cannot be disclosed
Organisation: Cannot be disclosed
Status: Still in development
Throughout a woman's life, the vaginal epithelium is subject to strong physiological variations which, combined with the use of external chemical molecules, can lead to intimate discomforts such as irritation, dryness and dysbiosis. The safety of these external agents, whether hygiene or skincare
Last updated on: 02-12-2024 - 09:28
The protocol is aimed at developing primary human breast organoids that have a morphology similar to the one observed in the in vivo breast. This morphology encompasses a complex network organization composed of interconnected branches that terminate in TDLU-like structures. The organoids are
Last updated on: 11-10-2024 - 15:19
Contact: Colinda Scheele
Organisation: Katholieke Universiteit Leuven (KUL), Oncology - KU Leuven
Status: Still in development, History of use, Published in peer reviewed journal
The mammary-specific polyomavirus middle T antigen overexpression mouse model (MMTV-PyMT) is one of the most commonly used models in the cancer research field for multiple reasons, among which the spontaneous development of multifocal luminal tumors, the early tumoral onset, and the primary tumors'
Last updated on: 11-10-2024 - 15:19
Contact: Colinda Scheele
Organisation: Oncology - KU Leuven, Katholieke Universiteit Leuven (KUL)
The protocol is aimed at developing primary mammary gland organoids that have a morphology similar to the one of the in vivo breast, which is organized as a complex network of interconnected branches. The organoids are derived from the mouse mammary gland by mechanical dissociation and enzymatic
Last updated on: 11-10-2024 - 15:19
Contact: Colinda Scheele
Organisation: Oncology - KU Leuven
Status: History of use, Published in peer reviewed journal
The extracellular matrix (ECM) is a highly organized tissue-specific network, which is secreted by tissue-resident cells and significantly influences cell phenotype, behaviour and function. The 3R principle calls for the replacement of animal models in areas like drug screening, and consequently,
Last updated on: 27-09-2024 - 16:39
Respiratory diseases are one of the leading causes of mortality. Despite the efforts to understand lung development, physiology, and pathology, this field remains in its early stages. In vitro models can replicate lung physiology to comprehend development, function, and pathology. Lung organoids
Last updated on: 25-09-2024 - 11:44
Contact: Alessandra Boggian
Organisation: Université Libre de Bruxelles (ULB)
Partners: Université Libre de Bruxelles (ULB)
Status: Still in development
