Studying spermatogenesis in situ has led to the understanding that the 3D reorganization of testicular cells into an interstitial and tubular compartment is of enormous importance for germ cell differentiation. We will rely on 3D bioprinting technology which gives control over cell deposition and

Last updated on: 06-10-2022 - 14:11

Contact: Guillaume Richer
Organisation: Vrije Universiteit Brussel (VUB)
Status: Still in development, Published in peer reviewed journal
The in vitro rumen fermentation technique is used to simulate the rumen function/fermentation. The rumen is the first compartment of the digestive tract of ruminants, in which feed - consumed by ruminants - is fermented by rumen microbes. For optimal fermentation, the rumen provides an anaerobic

Last updated on: 07-09-2022 - 16:36

Contact: Veerle Fievez
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
ZeptoWard is a Machine Learning solution (AI) which identifies the ADMET properties of compounds. It can accurately predict over 80 properties related to absorption, distribution, metabolism, excretion, and toxicity properties, how a specific compound or combination of compounds will perform. It can

Last updated on: 29-08-2022 - 10:03

Contact: Segolene Martin
Organisation: Kantify
Status: Published in peer reviewed journal
ZeptoHit is a technology based on Artificial Intelligence (AI) which accelerates hit discovery. With only a protein sequence as information, ZeptoHit can quickly and efficiently recommend promising hits, without any limitations. Its search for promising compounds goes much beyond chemical structures

Last updated on: 29-08-2022 - 09:57

Contact: Segolene Martin
Organisation: Kantify
Status: Internally validated, Published in peer reviewed journal
The tri-dimensional (3D) culture protocols allow isolation and culture of gastric epithelial antral and intestinal stem cells to efficiently generate organoids that recapitulate the mature pyloric and intestinal epithelium in vitro and foetal epithelial progenitors of these tissues growing as

Last updated on: 16-08-2022 - 10:57

Organisation: Université Libre de Bruxelles (ULB)
Status: History of use, Internally validated, Published in peer reviewed journal
For therapeutic or reporter molecules to be effective for therapy or imaging applications, proper accumulation of the compounds in the tissue of interest is required, with minimal accumulation in undesired organs to avoid toxic side-effects and increase bioavailability. After initial in vitro

Last updated on: 09-08-2022 - 16:34

Contact: Sophie Hernot
Organisation: Vrije Universiteit Brussel (VUB)
Status: History of use
The main objective of this research project is to create the first full-thickness cornea-on-chip, which comprises a 3D construct with every cellular layer of the cornea. This construct is embedded in a microfluidic chip with two channels that are continuously perfused. The epithelial side of the

Last updated on: 27-07-2022 - 09:35

Contact: Joris Van Meenen
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development
An artificial dog with real skeleton to excercise positioning for radiographic examination and palpation.

Last updated on: 25-07-2022 - 09:53

Organisation: Ghent University (UGent)
Status: Internally validated
A battery of in vitro genotoxicity assays is currently used to detect agents with DNA damaging and carcinogenic potential. Although the sensitivity of this battery of genotoxicity assays is high, the specificity is low (“false positive hit”), especially with the mammalian cell-based assay, compared

Last updated on: 11-07-2022 - 15:51

Contact: Marc Audebert
Organisation: Institut national de la recherche agronomique (INRAE)
Status: History of use, Internally validated, Published in peer reviewed journal, Currently submitted for further validation by an external party (e.g. OECD, EURL ECVAM,…)
DARTpaths is an an integrative app to support the prioritisation of chemicals. The Open Source R shiny application allows for the prediction of compound-induced molecular mechanisms of action. The tool integrates phenotypic endpoints of different species induced by compounds and genetic variants, in

Last updated on: 13-06-2022 - 16:04

Contact: Vera van Noort
Organisation: Katholieke Universiteit Leuven (KUL)
Partners: Open Analytics, Hogeschool Utrecht , Vivaltes
Status: Internally validated