We use HD-MEA recordings from hIPSC derived neuronal cultures to study network behavior of mutant and control cultures.
Last updated on: 16-07-2025 - 10:00
Contact: Sarah Weckhuysen
Organisation: Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp (UAntwerpen)
Status: Published in peer reviewed journal
Studying spermatogenesis in situ has led to the understanding that the 3D reorganization of testicular cells into an interstitial and tubular compartment is of enormous importance for germ cell differentiation. We will rely on 3D bioprinting technology which gives control over cell deposition and
Last updated on: 08-07-2025 - 10:26
Contact: Yoni Baert
Organisation: Vrije Universiteit Brussel (VUB)
Status: Still in development, Published in peer reviewed journal
The GENOMARK tool in metabolically competent human HepaRG cells is based on the transcriptomic results obtained with 12 genotoxic (in vivo positive results) and 12 non-genotoxic (in vivo negative results) reference compounds. Genotoxic compounds were selected to cover different mechanisms of action
Last updated on: 08-07-2025 - 10:07
Contact: Birgit Mertens
Organisation: Sciensano, Vrije Universiteit Brussel (VUB)
Status: Internally validated, Published in peer reviewed journal
Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations in various genes with fundamental roles in the development and function of peripheral nerves. Over the past 10 years, significant advances in identifying molecular disease mechanisms underlying axonal and
Last updated on: 08-07-2025 - 09:14
Contact: Vincent Timmerman
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development
The most commonly used readout for eye function in fruit flies is the electroretinogram (ERG). While ERGs are applied to study phototransduction, they also constitute a robust assay to assess neuronal communication between photoreceptors and second-order brain neurons. Using glass electrodes placed
Last updated on: 02-06-2025 - 10:09
Contact: Valerie Uytterhoeven
Organisation: VIB - KU Leuven, Neurosciences - KU Leuven, Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Longitudinal imaging of bioluminescent fungi in Galleria mellonella can complement standard survival and health scoring data by quantifying the fungal burden over time and monitoring early infection before clinical symptoms arise, and by more sensitively and more early detection of treatment effects
Last updated on: 28-05-2025 - 13:51
Contact: Eliane Vanhoffelen
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Internally validated, Published in peer reviewed journal
We developed a transgenic zebrafish line that expresses a genetically encoded calcium and voltage indicator in the heart, allowing us to assess cardiac action potentials and calcium transients in vivo at real time by analysing changes in fluorescent signal.
Last updated on: 08-05-2025 - 17:38
Contact: Dorien Schepers
Organisation: University of Antwerp (UAntwerpen)
Status: Internally validated
This method uses human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, to generate cortical brain organoids and model brain tumorigenesis through targeted genetic manipulation. The aim is to create a physiologically relevant, in vitro 3D system that mimics
Last updated on: 06-05-2025 - 15:34
Contact: Diana Al Delbany
Organisation: Vrije Universiteit Brussel (VUB)
Status: History of use, Internally validated, Published in peer reviewed journal
The Colon-on-a-plate® technology is a high-throughput biorelevant in vitro simulation of the physiology and microbiology of the colon. This robust screening technology is not limited to comparing the impact of tens of test product on the microbiome, but also offers insight into the factors
Last updated on: 11-04-2025 - 16:13
Contact: Cannot be disclosed
Organisation: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
The M-SHIME is a dynamic model for the human digestive tract that mimics the different compartments - stomach, small intestine and colon - while also incorporating a cross-sectional simulation mimicking both the luminal as the mucosal microenvironment of the human gut. The mucosal environment in
Last updated on: 04-03-2025 - 13:23
Contact: Tom Van de Wiele
Organisation: Ghent University (UGent)
Status: History of use, Internally validated, Published in peer reviewed journal
