Transdermal and transmucosal kinetics using FDC
Scope of the method
- Human health
- Basic Research
- In vitro - Ex vivo
- Human derived cells / tissues / organs
- skin absorption
Transport kinetics accross the skin and/or mucosa is investigated using Franz diffusion cells and LC-UV/MS detection of the investigated molecule in the receptor compartment.
- Franz diffusion cell system ;
- Internally validated
- Published in peer reviewed journal
Pros, cons & Future potential
No in vitro cell line is used but real ex vivo skin or mucosa.
References, associated documents and other information
Taevernier L, et al. (2016). Human skin permeation of emerging mycotoxins (beauvericin and enniatins). J Expo Sci Environ Epidemiol. 26(3):277-87.
Taevernier L, et al. (2015). Enniatin-containing solutions for oromucosal use: Quality-by-design ex-vivo transmucosal risk assessment of composition variability. Int J Pharm. 491(1-2):144-51.
Veryser L, et al. (2014). Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract. Phytomedicine. 21(14):1801-7.
Veryser L, et al. (2016). Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models. BMC Complement Altern Med. 16:177.
Contact personYorick Janssens