Monotonic dose-response testing for Nanomaterial toxicity

Commonly used acronym: NMTox

Scope of the method

The Method relates to
  • Animal health
  • Human health
The Method is situated in
  • Basic Research
  • Translational - Applied Research
Type of method
  • In silico
This method makes use of
  • Animal derived cells / tissues / organs


Method keywords
  • data exploration
  • dose response
  • monotonic trend
Scientific area keywords
  • nanomaterials
Method description

NMTox is an R-software package and a Shiny app that can be used to explore and subset large datasets and can identify and test for monotonic dose responses. The package was developed within the NanoInformaTIX project where a platform is developed that aims to predict nanomaterial toxicity.

Method status
  • Internally validated

Pros, cons & Future potential


Versatile tool to be used for several applications.


Learning curve if the R-package is used.

References, associated documents and other information

Associated documents
Dose-response modelling for NanoInformatics toxicity

Contact person

Geert Verheyen


Thomas More University of Applied Sciences

University of Hasselt (UHasselt)
Centrum voor Statistiek