The culture of primary human synoviocytes provides an excellent cellular model for studying the normal and pathological physiology of synoviocytes and the development of joint diseases. Human primary synoviocytes can either be provided by commercial suppliers or isolated from fresh biological
Last updated on: 17-01-2024 - 11:32
Alkaptonuria (AKU) is a rare inborn error of metabolism caused by a defective homogentisate 1,2-dioxygenase (HGD), an enzyme involved in the tyrosine degradation pathway. Loss of HGD function leads to the accumulation of homogentisic acid (HGA) in connective body tissues in a process called
Last updated on: 06-12-2023 - 14:45
Contact: Sien Lequeue
Organisation: Vrije Universiteit Brussel (VUB)
Partners: RWTH Aachen
Status: Published in peer reviewed journal
The maturation of the human brain shows species-specific differences of neoteny when compared to lower mammals. This process encompass a time window that expands from late embryonic stages to early adolescence. Major features of brain maturation are the acquisition of phenotypic complex traits such
Last updated on: 25-09-2023 - 14:38
Contact: Ira Espuny Camacho
Organisation: University of Liège (ULiège)
Status: Still in development, History of use
In contrast to human medicine, standard imaging techniques for cardiac interventions, namely fluoroscopy, CT and MRI, cannot be used in horses because the size of their thorax is too large for the gantry (CT and MRI) or results in insufficient detail (fluoroscopy). Therefore, echocardiography is
Last updated on: 20-09-2023 - 10:28
Severely burned skin can exhibit serious contractions that may negatively impact the mobility of joints of patients. The method deals with post-burn evolution of skin, in which one considers the balance of momentum, cells, collagen and chemokines. The balances are represented in terms of partial
Last updated on: 05-09-2023 - 11:43
Contact: Fred Vermolen
Organisation: University of Hasselt (UHasselt)
Status: Still in development, Internally validated, Published in peer reviewed journal
UHDR irradiations show healthy tissue sparing effect known as the FLASH effect. Since 2014, the FLASH effect is investigated worldwide to understand how it works and how to trigger it. The FLASH effect is defined as an in vivo effect. However, in vivo models are often expensive and time-consuming.
Last updated on: 05-09-2023 - 08:45
Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos
Zebrafish-based platforms have recently emerged as a useful tool for toxicity testing as they combine the advantages of in vitro and in vivo methodologies. Nevertheless, the capacity to metabolically convert xenobiotics by zebrafish eleuthero embryos is supposedly low. To circumvent this concern, a
Last updated on: 01-09-2023 - 09:55
Contact: Marie Pardon
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
The spatiotemporal distribution of fluorescent compounds was examined during 48 h after immersion (10 µM) or microinjection (2 mg/kg) in the pericardial cavity (PC), intraperitoneally (IP) and yolk sac (IY) of 3 dpf zebrafsh eleuthero-embryos. By modelling the fluorescence of whole-body contours
Last updated on: 01-09-2023 - 09:43
Contact: Marie Pardon
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Immersion treatment: zebrafish embryos at the two-cell stage were immersed in Danieau’s medium containing the compound. A compound concentration of 10 µM and DMSO concentration of 0.1% (v/v) in a volume of 5 mL was used per well (6-well-plates). At 72 h, the zebrafish medium containing the compound
Last updated on: 01-09-2023 - 09:32
Contact: Marie Pardon
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
NMTox is an R-software package and a Shiny app that can be used to explore and subset large datasets and can identify and test for monotonic dose responses. The package was developed within the NanoInformaTIX project where a platform is developed that aims to predict nanomaterial toxicity.
Last updated on: 22-08-2023 - 10:43
Contact: Geert Verheyen
Organisation: Thomas More University of Applied Sciences, University of Hasselt (UHasselt)
Status: Internally validated
