Aim: To model cartilage-related disorders in a human-specific context for the investigation of disease mechanisms and the screening of potential therapeutics.
Technique: Fibroblasts and/or peripheral blood mononuclear cells (PBMCs) from both healthy donors and patients are reprogrammed into
Last updated on: 07-08-2025 - 15:33
Contact: Pauline De Kinderen
Organisation: University of Antwerp (UAntwerpen)
Status: Internally validated
Thoracic aortic aneurysm (TAA) involves the progressive enlargement of the thoracic aorta, posing a significant risk for life-threatening aortic dissection and/or rupture. Currently, mouse models are frequently used to investigate and target the molecular defects underlying TAA, due to the
Last updated on: 06-08-2025 - 14:40
Contact: Ivanna Fedoryshchenko
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development
This method/PhD project explores an innovative approach using synthetic communities (SynComs) to develop vaginal therapeutics. First, a top-down approach will be used to screen and select consortia of vaginal microbiota, emphasizing synergistic interactions and eliminating antagonistic effects. A
Last updated on: 16-07-2025 - 10:51
Contact: Maline Victor
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development
Generation of cortical organoids from patient and control hIPSC.
Last updated on: 16-07-2025 - 10:01
Contact: Sarah Weckhuysen
Organisation: Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp (UAntwerpen)
Status: Internally validated
We generate iPSC derived neurons and astrocytes using NgN2, ASCL1 and SOX9 overexpression respectively.
Last updated on: 16-07-2025 - 10:00
Contact: Sarah Weckhuysen
Organisation: Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp (UAntwerpen)
Status: Published in peer reviewed journal
We use HD-MEA recordings from hIPSC derived neuronal cultures to study network behavior of mutant and control cultures.
Last updated on: 16-07-2025 - 10:00
Contact: Sarah Weckhuysen
Organisation: Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp (UAntwerpen)
Status: Published in peer reviewed journal
Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations in various genes with fundamental roles in the development and function of peripheral nerves. Over the past 10 years, significant advances in identifying molecular disease mechanisms underlying axonal and
Last updated on: 08-07-2025 - 09:14
Contact: Vincent Timmerman
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development
We developed a transgenic zebrafish line that expresses a genetically encoded calcium and voltage indicator in the heart, allowing us to assess cardiac action potentials and calcium transients in vivo at real time by analysing changes in fluorescent signal.
Last updated on: 08-05-2025 - 17:38
Contact: Dorien Schepers
Organisation: University of Antwerp (UAntwerpen)
Status: Internally validated
This method relates to the development of highly reproducible human iPSC-derived neurospheroids equipped with intrinsic bioluminescence for an easy and longitudinal follow-up of the viability and growth of these neurospheroids over time. The luminescent neurospheroids have been applied in ischemic
Last updated on: 02-01-2023 - 10:27
Contact: Elise Van Breedam
Organisation: University of Antwerp (UAntwerpen)
Status: Published in peer reviewed journal
The main objective of this research project is to create the first full-thickness cornea-on-chip, which comprises a 3D construct with every cellular layer of the cornea. This construct is embedded in a microfluidic chip with two channels that are continuously perfused. The epithelial side of the
Last updated on: 27-07-2022 - 09:35
Contact: Joris Van Meenen
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development
