For the generation of the human skin-derived precursors (hSKP) spheroids, ultra-low attachment 96-well plates, cell-repellent (Greiner) are used. hSKP cultured on tissue culture plates are detached with trypple (5 minutes) and collected in a tube. After centrifugation, hSKP are counted at the Burker
Last updated on: 23-07-2025 - 09:50
Contact: Robim Rodrigues
Organisation: Vrije Universiteit Brussel (VUB)
Status: Still in development
The large (1mm diameter), easily accessible eggs of the frog Xenopus laevis (100-1000 eggs at once per frog) offer the opportunity to reconstitute cell cycle events in-vitro by generating cell-free extracts which retain all the biochemical components that regulate cell cycle progression, as well as
Last updated on: 22-07-2025 - 09:40
Contact: Martina Boiardi
Organisation: Katholieke Universiteit Leuven (KUL), Cellular and Molecular Medicine - KU Leuven
Status: History of use, Published in peer reviewed journal
We developed a biventricular statistical shape model (SSM) from high-resolution cardiac CT scans from 271 healthy individuals. Leveraging the diversity captured by our biventricular SSM, we created a synthetic cohort of anatomically detailed, high-resolution, biventricular meshes. The geometries in
Last updated on: 16-07-2025 - 10:01
Contact: Lore Van Santvliet
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Generation of cortical organoids from patient and control hIPSC.
Last updated on: 16-07-2025 - 10:01
Contact: Sarah Weckhuysen
Organisation: Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp (UAntwerpen)
Status: Internally validated
We generate iPSC derived neurons and astrocytes using NgN2, ASCL1 and SOX9 overexpression respectively.
Last updated on: 16-07-2025 - 10:00
Contact: Sarah Weckhuysen
Organisation: Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp (UAntwerpen)
Status: Published in peer reviewed journal
We use HD-MEA recordings from hIPSC derived neuronal cultures to study network behavior of mutant and control cultures.
Last updated on: 16-07-2025 - 10:00
Contact: Sarah Weckhuysen
Organisation: Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp (UAntwerpen)
Status: Published in peer reviewed journal
Studying spermatogenesis in situ has led to the understanding that the 3D reorganization of testicular cells into an interstitial and tubular compartment is of enormous importance for germ cell differentiation. We will rely on 3D bioprinting technology which gives control over cell deposition and
Last updated on: 08-07-2025 - 10:26
Contact: Yoni Baert
Organisation: Vrije Universiteit Brussel (VUB)
Status: Still in development, Published in peer reviewed journal
The GENOMARK tool in metabolically competent human HepaRG cells is based on the transcriptomic results obtained with 12 genotoxic (in vivo positive results) and 12 non-genotoxic (in vivo negative results) reference compounds. Genotoxic compounds were selected to cover different mechanisms of action
Last updated on: 08-07-2025 - 10:07
Contact: Birgit Mertens
Organisation: Sciensano, Vrije Universiteit Brussel (VUB)
Status: Internally validated, Published in peer reviewed journal
Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations in various genes with fundamental roles in the development and function of peripheral nerves. Over the past 10 years, significant advances in identifying molecular disease mechanisms underlying axonal and
Last updated on: 08-07-2025 - 09:14
Contact: Vincent Timmerman
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development
The most commonly used readout for eye function in fruit flies is the electroretinogram (ERG). While ERGs are applied to study phototransduction, they also constitute a robust assay to assess neuronal communication between photoreceptors and second-order brain neurons. Using glass electrodes placed
Last updated on: 02-06-2025 - 10:09
Contact: Valerie Uytterhoeven
Organisation: VIB - KU Leuven, Neurosciences - KU Leuven, Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
