News & Events

Clostridium septicum vaccine as a proof of concept

Three cell-based assays have been validated, through collaborative study BSP130, to replace the current animal tests required for in-process quality control of Clostridium septicum vaccines. The webinars aim to disseminate the study results, share knowledge, facilitate discussions between stakeholders and provide information on the implementation of the model for other clostridial vaccines.

This webinar is part of the series on the use of New Approach Methodologies (NAMs) in Risk Assessment.

During this talk the development of an AOP framework for carcinogenicity and how it could be used as evidence in an IATA for a substance in assessing its carcinogenic risk will be presented. Also, an expert system for predicting carcinogenicity concerns and its use in the EPA’s New Chemicals Program will be discussed.

This training will cover the general principles of risk assessment of chemicals, food safety, and cosmetics. During a hands-on session, participants will have the opportunity to practice how to derive the safety level of some chemicals.

More information and registration: caat-eu-2@uni-konstanz.de

The webinar will showcase the solution of the 2012 PreDART CRACK IT Challenge which is a C. elegans platform to assess the developmental and reproductive toxicity (DART) potential of chemicals developed by a team of scientists from the Institute for Risk Assessment Sciences (Utrecht University). 

This training will deepen participants' knowledge on the applications and use of Multi-Organ-Chip-based models in the context of Safety and efficacy evaluation. The topics covered include:  1. Handling of the Multi-Organ-Chip (MOC) technology of TissUse, 2. Visible observation of chips production, 3. Implementation of cells & organ models into the MOC, 4. Cultivation of MOC, ...

The conference will highlight the latest information on the regulatory use of QSAR and Read-Across. A particular focus will be put on (i) developing practical examples and recent experiences of applying QSARs to assess genotoxicity; and (ii) exploring the opportunities and challenges of using read-accross in general toxicity assessment.

The workshop is part of the Putting Science into Standards (PSIS) initiative which aims to facilitate the identification of emerging science and technology areas that could benefit from standardisation activities and foster innovation and industrial competitiveness.

During this event, various stakeholders will exchange their views on the application, further development and effective implementation of the Organ-on-Chip technology in the regulatory framework.

During this event, the future development of Organ-on-Chip (OoC) or Micro Physiological Systems (MPS) technology will be discussed. Particularly, the areas of application and stakeholder needs to facilitate their implementation in the regulatory framework, thereby advancing further the replacement of animal use in testing.