The M-SHIME is a dynamic model for the human digestive tract that mimics the different compartments - stomach, small intestine and colon - while also incorporating a cross-sectional simulation mimicking both the luminal as the mucosal microenvironment of the human gut. The mucosal environment in
Last updated on: 04-03-2025 - 13:23
Contact: Tom Van de Wiele
Organisation: Ghent University (UGent)
Status: History of use, Internally validated, Published in peer reviewed journal
The BALB/c-derived - 4T1 mammary tumor cell line and RAW264.7 macrophage cell line were maintained in Dulbecco’s Modified Eagle’s Medium (DMEM) supplemented with 10% heat-inactivated fetal bovine serum (FBS), 100 U/ml penicillin and 100 μg/ml streptomycin in culture flasks. Harvesting of cultured
Last updated on: 28-01-2025 - 16:41
Contact: Kristel Demeyere
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
The extracellular matrix (ECM) is a highly organized tissue-specific network, which is secreted by tissue-resident cells and significantly influences cell phenotype, behaviour and function. The 3R principle calls for the replacement of animal models in areas like drug screening, and consequently,
Last updated on: 27-09-2024 - 16:39
Overuse tendon injuries are a major cause of musculoskeletal morbidity in both human and equine athletes. Despite the big burden, there is no effective treatment to restore tendon’s natural composition, due to a lack of understanding of fundamental cell biology. Additionally, translation of novel
Last updated on: 12-08-2024 - 09:32
The application of liver organoids is very promising in the field of liver tissue engineering; however, it is still facing some limitations. One of the current major limitations is the matrix in which they are cultured. The mainly undefined and murine-originated tumor matrices derived from
Last updated on: 22-01-2024 - 17:28
Contact: Nathan Carpentier
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
In contrast to human medicine, standard imaging techniques for cardiac interventions, namely fluoroscopy, CT and MRI, cannot be used in horses because the size of their thorax is too large for the gantry (CT and MRI) or results in insufficient detail (fluoroscopy). Therefore, echocardiography is
Last updated on: 20-09-2023 - 10:28
In the skillslab, dummy models and simulators are used for teaching various clinical skills. The veterinarians in training need to learn how to assist the calving process in the cow and how to perform artifical insemination and rectal palpation in cows. Although training on living animals is
Last updated on: 28-06-2023 - 13:53
Contact: Annelies Decloedt
Organisation: Ghent University (UGent)
Status: Still in development, History of use, Internally validated
In the skillslab, dummy models and simulators are used for teaching various clinical skills. The veterinarians in training need to learn how to handle cows and pigs in a correct and safe way. Although training on living animals is indispensable, a part of the training process can be performed on
Last updated on: 28-06-2023 - 13:53
Contact: Annelies Decloedt
Organisation: Ghent University (UGent)
Status: History of use, Internally validated
In the skillslab, dummy models and simulators are used for teaching various clinical skills. The veterinarians in training need to learn how to monitor and approach an animal under anesthesia. Furthermore, they need to learn ventilation techniques and comprehension of an anesthetic machine. An
Last updated on: 23-06-2023 - 17:14
Contact: Annelies Decloedt
Organisation: Ghent University (UGent)
Status: History of use, Internally validated
In the skillslab, dummy models and simulators are used for teaching various clinical skills. Endotracheal intubation after induction of anesthesia is an important and commonly performed procedure in veterinary practice. An important part of this training process can be performed on a simulator in
Last updated on: 23-06-2023 - 17:13
Contact: Annelies Decloedt
Organisation: Ghent University (UGent)
Status: History of use, Internally validated
