Sandwich-cultured hepatocytes are exposed to test compounds (e.g. drug candidates) or known hepatotoxicants (as controls) both in the absence and in the presence of a mixture of physiologically relevant bile acids. After 24h, decreased hepatocyte viability and functionality in the presence of

Last updated on: 30-08-2019 - 09:25

Contact: Pieter Annaert
Organisation: KU Leuven
Status: Internally validated, Published in peer reviewed journal

Prototyping and replication (small series production) of microfluidic or optofluidic devices, in thermoplastic polymers or in glass. 3D nanoprinting is also available to produce microscaffolds, possibly within microfluidic channels.

Last updated on: 29-08-2019 - 15:06

Contact: Jürgen Van Erps
Organisation: Vrije Universiteit Brussel
Status: Internally validated, Published in peer reviewed journal

The cardiorespiratory model reproduces human physiology with a high level of fidelity. It is a lumped parameter model including a representation of atria, ventricles, pulmonary and systemic circulations, autonomic controls, metabolic peripheral control, ventilation and gas exchange in tissues and

Last updated on: 29-08-2019 - 13:42

Contact: Libera Fresiello
Organisation: Cannot be disclosed
Partners: Cannot be disclosed
Status: History of use, Internally validated, Published in peer reviewed journal

Recent improvements on the structural aspects of organ-on-chips pave the way towards a large-scale application. As such soon the number of read-out instruments that are in operation in parallel will need to drastically increase. Unfortunately, standard read-out equipment is bulky, complex and

Last updated on: 27-08-2019 - 18:22

Organisation: Vrije Universiteit Brussel
Status: Still in development

Despite major advances in our understanding of neurodegenerative disorders, no efficient therapies are available for patients with dementia, motor neuron disease and other neurodegenerative disorders. With the advent of pluripotent stem cells (PSCs) it now becomes possible to better model human

Last updated on: 27-08-2019 - 18:22

Contact: Cannot be disclosed
Organisation: KU Leuven
Status: Still in development, Internally validated

With a one vessel fermentor (BioFlo 110, New Brunswick), an in vitro simulation of a certain part of the gastrointestinal tract (e.g. cecum, colon) is performed. In this fermentation system, physiological gut parameters (pH, temperature) are kept constant, while chemico-physical

Last updated on: 27-08-2019 - 18:17

Contact: Marc Heyndrickx
Organisation: Flanders Research Institute for Agriculture
Status: History of use, Internally validated, Published in peer reviewed journal

This method is used to monitor cardiac cell cultures in vitro. It can be used for monitoring both cell activity and drug-induced cardiac side-effects for primary cardiomyocytes or hIPSC-derived cardiomyocytes. Unlike conventional microelectrode array systems that only measure the local

Last updated on: 26-08-2019 - 14:16

Contact: Thomas Pauwelyn
Organisation: IMEC
Status: Published in peer reviewed journal

We developed in vitro models to study liver disease, such as liver inflammation and fibrosis, as seen in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH); or hepatitis viral infection; or to enhance our ability to detect drugs that cause acute or repeat dose

Last updated on: 26-08-2019 - 13:56

Contact: Cannot be disclosed
Organisation: KU Leuven
Status: Internally validated, Published in peer reviewed journal

The scope of our research ranges from the study of flow and transport processes in blood and biological fluids in the cardiovascular system and artificial organs to biomechanical aspects of the cardiovascular and the skeleto-muscular system and medical devices. All research tracks explored by our

Last updated on: 12-07-2019 - 16:55

Contact: Patrick Segers
Organisation: Ghent University