For the risk assessment of compounds migrating from food contact materials (FCM), information on the exposure to the migrant as well as its possible hazards is needed. To support the evaluation of both starting products and NIAS from plastic FCM, the VERMEER FCM tool has been developed within the
Last updated on: 27-06-2025 - 09:57
Longitudinal imaging of bioluminescent fungi in Galleria mellonella can complement standard survival and health scoring data by quantifying the fungal burden over time and monitoring early infection before clinical symptoms arise, and by more sensitively and more early detection of treatment effects
Last updated on: 28-05-2025 - 13:51
Contact: Eliane Vanhoffelen
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Internally validated, Published in peer reviewed journal
Cholestatic drug-induced liver injury (cDILI) is a frequent reason for drug failure and withdrawal during premarketing and postmarketing stages of drug development. Strategies for reliable detection of cDILI in early drug development are therefore urgently needed. The drug-induced cholestasis index
Last updated on: 23-04-2025 - 11:36
Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: Published in peer reviewed journal
The Colon-on-a-plate® technology is a high-throughput biorelevant in vitro simulation of the physiology and microbiology of the colon. This robust screening technology is not limited to comparing the impact of tens of test product on the microbiome, but also offers insight into the factors
Last updated on: 11-04-2025 - 16:13
Contact: Cannot be disclosed
Organisation: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
The M-SHIME is a dynamic model for the human digestive tract that mimics the different compartments - stomach, small intestine and colon - while also incorporating a cross-sectional simulation mimicking both the luminal as the mucosal microenvironment of the human gut. The mucosal environment in
Last updated on: 04-03-2025 - 13:23
Contact: Tom Van de Wiele
Organisation: Ghent University (UGent)
Status: History of use, Internally validated, Published in peer reviewed journal
Identifying drug-target interactions is a crucial step in drug repositioning, the process of suggesting new indications for known drugs. There are about 9000 FDA-approved and experimental small molecule drugs and more than 500.000 protein records available. Performing in vitro experiments would be
Last updated on: 28-01-2025 - 16:41
Contact: Daniele Parisi
Organisation: Katholieke Universiteit Leuven (KUL)
Partners: Biotech/TU-Dresden, Max-Planck-Institut für Informatik Saarbrucken
Status: Still in development
Human embryonic kidney (HEK) 293 FT cells is a celline that is very easy to culture and is used to obtain high viral titers. “293” is a reference to the 293th experiment wherein the cell line was discovered. A transfection with an adenovirus type 5 DNA fragment took place, causing the cell line to
Last updated on: 28-01-2025 - 15:12
Human duodenal biopsies from metabolic dysfunction-associated steatohepatitis (MASH) patients were used to generate organoids and then investigate potential alterations in intestinal barrier and absorptive functions.
Last updated on: 19-12-2024 - 09:15
Contact: Marie-Isabelle Garcia
Organisation: Université Libre de Bruxelles (ULB)
Partners: Université Libre de Bruxelles (ULB)
Status: Published in peer reviewed journal
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were seeded in 48-well multielectrode array (MEA) plates and were treated with four doses of reference compounds (covering and exceeding clinical free plasma peak concentrations) and MEA recordings were conducted for 4 days.
Last updated on: 13-12-2024 - 14:46
Contact: Cannot be disclosed
Organisation: Janssen Pharma of JNJ
Status: Internally validated, Published in peer reviewed journal
Design and fabrication of a method to enhance the cost-effectiveness of organoid culturing and drug screening assays by miniaturizing the cultures and reduce the required reagent volumes to the sub-nanoliter range through microfluidic techniques. By growing single or multiple organoids per microbead
Last updated on: 02-12-2024 - 15:51
Contact: Cannot be disclosed
Organisation: Cannot be disclosed
Status: Still in development
