Longitudinal imaging of bioluminescent fungi in Galleria mellonella can complement standard survival and health scoring data by quantifying the fungal burden over time and monitoring early infection before clinical symptoms arise, and by more sensitively and more early detection of treatment effects
Last updated on: 28-05-2025 - 13:51
Contact: Eliane Vanhoffelen
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Internally validated, Published in peer reviewed journal
We developed a transgenic zebrafish line that expresses a genetically encoded calcium and voltage indicator in the heart, allowing us to assess cardiac action potentials and calcium transients in vivo at real time by analysing changes in fluorescent signal.
Last updated on: 08-05-2025 - 17:38
Contact: Dorien Schepers
Organisation: University of Antwerp (UAntwerpen)
Status: Internally validated
This method uses human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, to generate cortical brain organoids and model brain tumorigenesis through targeted genetic manipulation. The aim is to create a physiologically relevant, in vitro 3D system that mimics
Last updated on: 06-05-2025 - 15:34
Contact: Diana Al Delbany
Organisation: Vrije Universiteit Brussel (VUB)
Status: History of use, Internally validated, Published in peer reviewed journal
The Colon-on-a-plate® technology is a high-throughput biorelevant in vitro simulation of the physiology and microbiology of the colon. This robust screening technology is not limited to comparing the impact of tens of test product on the microbiome, but also offers insight into the factors
Last updated on: 11-04-2025 - 16:13
Contact: Cannot be disclosed
Organisation: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
The M-SHIME is a dynamic model for the human digestive tract that mimics the different compartments - stomach, small intestine and colon - while also incorporating a cross-sectional simulation mimicking both the luminal as the mucosal microenvironment of the human gut. The mucosal environment in
Last updated on: 04-03-2025 - 13:23
Contact: Tom Van de Wiele
Organisation: Ghent University (UGent)
Status: History of use, Internally validated, Published in peer reviewed journal
The BALB/c-derived - 4T1 mammary tumor cell line and RAW264.7 macrophage cell line were maintained in Dulbecco’s Modified Eagle’s Medium (DMEM) supplemented with 10% heat-inactivated fetal bovine serum (FBS), 100 U/ml penicillin and 100 μg/ml streptomycin in culture flasks. Harvesting of cultured
Last updated on: 28-01-2025 - 16:41
Contact: Kristel Demeyere
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
Human embryonic kidney (HEK) 293 FT cells is a celline that is very easy to culture and is used to obtain high viral titers. “293” is a reference to the 293th experiment wherein the cell line was discovered. A transfection with an adenovirus type 5 DNA fragment took place, causing the cell line to
Last updated on: 28-01-2025 - 15:12
The Chorioallantoic Membrane (CAM) assay is a versatile, cost-effective in ovo model using the vascular-rich membrane of fertilized chicken eggs to study biological processes such as angiogenesis, tumor growth, metastasis, and drug testing. Its transparency and rapid vascularization make it ideal
Last updated on: 19-12-2024 - 11:45
Contact: Lotte Alders
Organisation: University of Hasselt (UHasselt)
Status: History of use, Published in peer reviewed journal
Human duodenal biopsies from metabolic dysfunction-associated steatohepatitis (MASH) patients were used to generate organoids and then investigate potential alterations in intestinal barrier and absorptive functions.
Last updated on: 19-12-2024 - 09:15
Contact: Marie-Isabelle Garcia
Organisation: Université Libre de Bruxelles (ULB)
Partners: Université Libre de Bruxelles (ULB)
Status: Published in peer reviewed journal
Design and fabrication of a method to enhance the cost-effectiveness of organoid culturing and drug screening assays by miniaturizing the cultures and reduce the required reagent volumes to the sub-nanoliter range through microfluidic techniques. By growing single or multiple organoids per microbead
Last updated on: 02-12-2024 - 15:51
Contact: Cannot be disclosed
Organisation: Cannot be disclosed
Status: Still in development
