Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were seeded in 48-well multielectrode array (MEA) plates and were treated with four doses of reference compounds (covering and exceeding clinical free plasma peak concentrations) and MEA recordings were conducted for 4 days.
Last updated on: 13-12-2024 - 14:46
Contact: Cannot be disclosed
Organisation: Janssen Pharma of JNJ
Status: Internally validated, Published in peer reviewed journal
Design and fabrication of a method to enhance the cost-effectiveness of organoid culturing and drug screening assays by miniaturizing the cultures and reduce the required reagent volumes to the sub-nanoliter range through microfluidic techniques. By growing single or multiple organoids per microbead
Last updated on: 02-12-2024 - 15:51
Contact: Cannot be disclosed
Organisation: Cannot be disclosed
Status: Still in development
Respiratory diseases are one of the leading causes of mortality. Despite the efforts to understand lung development, physiology, and pathology, this field remains in its early stages. In vitro models can replicate lung physiology to comprehend development, function, and pathology. Lung organoids
Last updated on: 25-09-2024 - 11:44
Contact: Alessandra Boggian
Organisation: Université Libre de Bruxelles (ULB)
Partners: Université Libre de Bruxelles (ULB)
Status: Still in development
Total Parenteral Nutrition (TPN) can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. Despite numerous
Last updated on: 10-09-2024 - 13:54
Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: Published in peer reviewed journal
Dental pulp stem cells (DPSC) are mesenchymal stem cells residing within the inner mucoid core (dental pulp) of teeth, responsible for tissue turnover and regeneration. Since third molars, or wisdom teeth, are frequently extracted for orthodontic reasons, DPSC are a highly accessible stem cell
Last updated on: 23-08-2024 - 11:01
Contact: Nathalie Dirkx
Organisation: University of Hasselt (UHasselt)
Partners: University of Hasselt (UHasselt)
Status: Still in development, History of use, Internally validated, Published in peer reviewed journal
Overuse tendon injuries are a major cause of musculoskeletal morbidity in both human and equine athletes. Despite the big burden, there is no effective treatment to restore tendon’s natural composition, due to a lack of understanding of fundamental cell biology. Additionally, translation of novel
Last updated on: 12-08-2024 - 09:32
The use of three-dimensional (3D) cell culture models is considered a reliable model that is successfully used for high-throughput drug testing in carcinoma research. However, the development of soft tissue sarcoma organoids is lagging behind. Soft tissue sarcoma is a group of rare malignancies from
Last updated on: 30-07-2024 - 12:08
Contact: Agnieszka Wozniak
Organisation: Oncology - KU Leuven, Katholieke Universiteit Leuven (KUL)
Status: Still in development
The SHIME® (Simulator of Human Intestinal Microbial Ecosystem) model is currently the most representative in vitro technology for the combined simulation of the physiological, chemical and microbiological properties of the gastrointestinal tract. The model enables study of the impact of long-term
Last updated on: 26-07-2024 - 09:49
Contact: Cannot be disclosed
Organisation: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
A proprietary designed lab-scale bioreactor containing a substrate for adherent cells and customized conditions, enabling the differentiation of MSCs into osteogenic lineage. The cell-substrate interaction can be assessed after prolonged 3D cell culture. Customizable and tunable to the experimental
Last updated on: 17-07-2024 - 08:28
Using the combination of advanced CRIPSR tools including several Cas orthologs, based editors (ABE, CBE, CGBE) and prime editing technologie with efficient delivery vehicles such as LV, AAV and virus-like particles (VLPs), our lab has become experienced with introducing or replacing precise edits in
Last updated on: 21-06-2024 - 11:29
Contact: Marianne Carlon
Organisation: Katholieke Universiteit Leuven (KUL)
Partners: Katholieke Universiteit Leuven (KUL)
Status: Still in development, Internally validated
