The protocol is aimed at developing primary human breast organoids that have a morphology similar to the one observed in the in vivo breast. This morphology encompasses a complex network organization composed of interconnected branches that terminate in TDLU-like structures. The organoids are
Last updated on: 11-10-2024 - 15:19
Contact: Colinda Scheele
Organisation: Katholieke Universiteit Leuven (KUL), Oncology - KU Leuven
Status: Still in development, History of use, Published in peer reviewed journal
The mammary-specific polyomavirus middle T antigen overexpression mouse model (MMTV-PyMT) is one of the most commonly used models in the cancer research field for multiple reasons, among which the spontaneous development of multifocal luminal tumors, the early tumoral onset, and the primary tumors'
Last updated on: 11-10-2024 - 15:19
Contact: Colinda Scheele
Organisation: Oncology - KU Leuven, Katholieke Universiteit Leuven (KUL)
The protocol is aimed at developing primary mammary gland organoids that have a morphology similar to the one of the in vivo breast, which is organized as a complex network of interconnected branches. The organoids are derived from the mouse mammary gland by mechanical dissociation and enzymatic
Last updated on: 11-10-2024 - 15:19
Contact: Colinda Scheele
Organisation: Oncology - KU Leuven
Status: History of use, Published in peer reviewed journal
The extracellular matrix (ECM) is a highly organized tissue-specific network, which is secreted by tissue-resident cells and significantly influences cell phenotype, behaviour and function. The 3R principle calls for the replacement of animal models in areas like drug screening, and consequently,
Last updated on: 27-09-2024 - 16:39
Respiratory diseases are one of the leading causes of mortality. Despite the efforts to understand lung development, physiology, and pathology, this field remains in its early stages. In vitro models can replicate lung physiology to comprehend development, function, and pathology. Lung organoids
Last updated on: 25-09-2024 - 11:44
Contact: Alessandra Boggian
Organisation: Université Libre de Bruxelles (ULB)
Partners: Université Libre de Bruxelles (ULB)
Status: Still in development
Total Parenteral Nutrition (TPN) can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. Despite numerous
Last updated on: 10-09-2024 - 13:54
Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: Published in peer reviewed journal
Dental pulp stem cells (DPSC) are mesenchymal stem cells residing within the inner mucoid core (dental pulp) of teeth, responsible for tissue turnover and regeneration. Since third molars, or wisdom teeth, are frequently extracted for orthodontic reasons, DPSC are a highly accessible stem cell
Last updated on: 23-08-2024 - 11:01
Contact: Nathalie Dirkx
Organisation: University of Hasselt (UHasselt)
Partners: University of Hasselt (UHasselt)
Status: Still in development, History of use, Internally validated, Published in peer reviewed journal
Overuse tendon injuries are a major cause of musculoskeletal morbidity in both human and equine athletes. Despite the big burden, there is no effective treatment to restore tendon’s natural composition, due to a lack of understanding of fundamental cell biology. Additionally, translation of novel
Last updated on: 12-08-2024 - 09:32
The use of three-dimensional (3D) cell culture models is considered a reliable model that is successfully used for high-throughput drug testing in carcinoma research. However, the development of soft tissue sarcoma organoids is lagging behind. Soft tissue sarcoma is a group of rare malignancies from
Last updated on: 30-07-2024 - 12:08
Contact: Agnieszka Wozniak
Organisation: Oncology - KU Leuven, Katholieke Universiteit Leuven (KUL)
Status: Still in development
The Colon-on-a-plate® technology is a high-throughput biorelevant in vitro simulation of the physiology and microbiology of the colon. This robust screening technology is not limited to comparing the impact of tens of test product on the microbiome, but also offers insight into the factors
Last updated on: 26-07-2024 - 09:50
Contact: Cannot be disclosed
Organisation: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
